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Targeted Protein Degradation Barcelona Summit 2025

The Targeted Protein Degradation Summit 2025 is a premier global gathering of scientists, biotech leaders, and innovators transforming drug discovery through the degradation of
disease-driving proteins.

ENQUIRE NOW
  • +420 776 164 009 (Prague office)
  • info@twoknctmedia.com
October 23rd /24th 2025
Barcelona, Spain
Registration

Conference Introduction

Across two dynamic days in Barcelona, we’ll dive deep into the latest advances in PROTACs, molecular glues, novel ligase targeting, and emerging platforms like LYTACs and DUBTACs. From early discovery to the clinic, the field is evolving rapidly — and this event is your opportunity to stay ahead, form partnerships, and help shape the future of small- molecule precision medicine.

6 Key Themes for the TPD Summit 2025

  1. Innovations in Degrader Chemistry: Advancing bifunctional and monovalent degraders: PROTACs, glues, covalent binders 
  2. Expanding the E3 Ligase Toolbox: Novel ligases, tissue specificity, and targeted degradation strategies
  3. Structural Biology & Rational Design: Ternary complex dynamics, modeling, and degrader-enabled selectivity
  4. PK/PD, Bioavailability & Drug-Like Properties: Oral delivery, blood–brain barrier access, and degradation kinetics
  5. Clinical Translation & Biomarker Strategies: First-in-human studies, pharmacodynamic endpoints, and trial design
  6. Emerging Modalities in Protein Degradation: LYTACs, AUTACs, DUBTACs, and new frontiers in subcellular targeting

Who Should Attend

Who Should Attend

  • Medicinal Chemists & Structural Biologists: Driving rational degrader design and ligand discovery 
  • Drug Discovery Scientists & Pharmacologists: Exploring new modalities for undruggable targets 
  • Biotech & Pharma Executives: Leading R&D, BD, and clinical strategy in TPD programs
  • Clinical Development Leaders: Advancing degraders through preclinical and early-phase trials
  • Computational Biologists & Platform Engineers: Enabling in silico modeling, AI-driven design, and degrader screening
  • Investors & Venture Capitalists: Seeking the next wave of innovation in oncology, neuro, and inflammation 
  • Regulatory & IP Professionals: Navigating new frameworks for novel mechanisms of action

Industries Represented

  • Small Molecule Drug Discovery
  • Biopharma & Degrader-Platform Biotech
  • Structural & Computational Biology
  • CROs & Preclinical Services
  • Medicinal & Synthetic Chemistry
  • Pharmaceutical IP & Legal
  • Venture Capital & Strategic Partnerships

Key Themes and Topics

  • Fundamentals of Flow Chemistry: The conference begins with an exploration of the fundamental principles and concepts underlying flow chemistry, including reactor configurations, reaction kinetics, and key advantages over traditional batch processes.
  • Applications Across Industries: Attendees will gain insights into the diverse applications of flow chemistry across various industries, including pharmaceuticals, fine chemicals, petrochemicals, materials science, and biotechnology. Case studies and success stories will highlight the practical implementation of flow chemistry in real-world manufacturing processes.
  • Advanced Techniques and Innovations: The conference will showcase cuttingedge developments and innovations in flow chemistry techniques, such as flow electrochemistry, flow photochemistry, and flow biocatalysis. Participants will learn about the latest methodologies and technologies pushing the boundaries of chemical synthesis and process optimization.
  • Practical Considerations and Challenges: Practical aspects of flow chemistry, including reactor design, instrumentation, automation, and scalability, will be discussed. Challenges such as regulatory compliance, safety considerations, and integration with existing processes will also be addressed.
  • Sustainability and Green Chemistry: Flow chemistry’s role in promoting sustainable manufacturing practices and reducing environmental impact will be a central theme. Attendees will explore how flow chemistry enables greener and more efficient chemical processes through reduced waste generation, energy consumption, and solvent usage.
  • Future Directions and Opportunities: The conference will conclude with a forward-looking perspective on the future of flow chemistry, highlighting emerging trends, opportunities for innovation, and potential applications in areas such as continuous manufacturing, personalized medicine, and advanced materials.

Day 1 – Discovery Biology, Chemistry & Emerging Modalities

09:00
Opening Keynote: “Targeted Protein Degradation Comes of Age”
  • Evolution of the field: From academic concept to clinical pipelines 
  • State of biotech and pharma investment 
  • Future directions in undruggable targets
09:30
Session 1: Degrader Chemistry – PROTACs & Beyond
  • Rational design of heterobifunctional degraders
  • Advances in linker chemistry and selectivity
  • Molecular glues: small and potent — where are we now?
11:00
Coffee & Networking Break
11:30
Session 2: E3 Ligase Biology & Targeting
  • Expanding the E3 ligase toolbox
  • Ligase expression profiles and disease relevance 
  • Ligase hijacking and tissue-specific degradation strategies
01:00
Networking Lunch
02:00
Session 3: Structural Biology & Rational Design
  • Cryo-EM and crystallography in degrader discovery 
  • Protein–ligase–degrader ternary complexes 
  • Modeling degrader-induced proximity and dynamics
03:30
Session 4: Target Validation & Mechanistic Studies
  • Confirming degradation vs. inhibition
  • Tools: PROTAC-specific controls, degradation assays, degron mapping
  • Case studies in oncology, neurodegeneration, and immunology
05:00
Panel: Degrading the Undruggable — Reality or Hype?
  • Which targets are truly “undruggable”? 
  • Degradation vs. inhibition: when is it worth it?
  • Industry, academic, and investor perspectives

Day 2 – Translation, Delivery & Clinical Development

09:00
Session 5: PK/PD, ADME & Bioavailability of Degraders
  • Pharmacokinetic challenges of bifunctional molecules 
  • Oral bioavailability strategies
  • Blood–brain barrier penetration and CNS applications
10:30
Coffee & Networking Break
11:00
Session 6: Pipeline Progress & Clinical Updates
  • First-in-human updates from Phase I/II trials 
  • Biomarkers and pharmacodynamic readouts
  • Case studies: Arvinas, C4 Therapeutics, Nurix, Kymera
12:30
Networking Lunch + Poster Session
01:30
Session 7: Emerging Modalities in Protein Degradation
  • LYTACs, AUTACs, DUBTACs: next-generation tools 
  • Targeting extracellular, mitochondrial, and membrane proteins 
  • Comparing bifunctional and monovalent approaches
03:00
Session 8: Regulatory, IP & Strategic Considerations
  • Regulatory guidance for novel mechanisms of action
  • IP landscape: composition of matter, linker space, and ligase targets
  • Partnering trends and big pharma strategy
04:30
Closing Panel: The Future of Protein Degradation
  • Industry vision: What does success look like in 2030?
  • Combining degradation with other modalities (e.g., immunotherapy, RNA)
  • Opportunities for investment, platform expansion, and clinical integration

Events

REGISTRATION FORM

Registration

DELEGATE PACKAGES:

NONPROFIT
PACKAGE

For academics and nonprofit organization.
Includes the delegate package benefits

799 €
STARTUP
PACKAGE

For small companies and startups.
Includes the delegate package benefits.

899 €
STANDARD
DELEGATE

2 days of conference + discussion with industry experts.
Business lunches and cocktail reception

1299 €
VIP DELEGATE PACKAGE

2 days of conference + discussion with industry experts.
2 nights luxury accommodation + transportation service from
airport to hotel. Businesslunches and cocktail reception

1999 €
  • +420 776 164 009
  • info@twoknctmedia.com

SPONSORSHIP PACKAGE

Our sponsorship packages are designed to offer optimum exposure for the budget that are available. For more information on the packages and to discuss your sponsorship requirements, please contact jakub.taborsky@twoknct.net

If you have any specific requirements that you feel are not covered by the packages available, then please do not hesitate to get in touch. We are always available to help you identify the options that suit your budget while maximizing your value and visibility at the conference.
KEYNOTE
EXHIBITION
SILVER
GOLD
PLATINUM
PEOPLE ATTENDANCE
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LOGO ON CONFERENCE WEBSITE, PROGRAM AND OTHER MARKETING MATERIALS OR POST-Workshop COMMUNICATION ACTIVITIES
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SOCIAL MEDIA PROMOTION
0
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AD PLACED IN FINAL CONFERENCE PROGRAM
0
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QUARTER PAGE
HALF PAGE
FULL PAGE
DISCOUNT FOR ADDITIONAL PASSES
10%
10%
10%
10%
10%
PROMO MATERIALS IN CONFERENCE BAGS (ONE A4 YER) PROVIDED BY SPONSOR
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LIST OF ATTENDEES
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ACKNOWLEDGEMENT DURING THE OPENING OF THE CONFERENCE
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OPPORTUNITY TO GIVE A SPEECH AT THE BEGINNING OF CONFERENCE
10 min
10 min
10 min
EXHIBITION BOOTH
3 SQ. M.
6SQ. M
VIP TABLE AT SELECTED SOCIAL Workshop
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BUSINESS LUNCHES AND COCKTAIL RECEPTION
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SPEAKING SLOT
30 min
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30 min
€ 3,995
€5,995
€6,999
€ 9,999
€ 14,999

COCKTAIL RECEPTION PACKAGE:

Includes the delegate package benefits + 10 min speaking slot + logo on website, program and other marketing materials + acknowledgement during cocktail reception

3499 €

DINNER SPONSORSHIP PACKAGE:

includes the delegate package benefits (with 2 people attendance) + 10 min speaking slot + panelist speaker slot on one conference panel discussion + logo on website, program and other marketing materials + acknowledgement during dinner

6999 €

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