TwoKnct Media & Publishing

In Vivo Gene Editing: From Bench to Bedside

Welcome to the In Vivo Gene Editing Conference 2025 — a premier global gathering of scientists, clinicians, and innovators advancing the real-world application of gene editing. Over two immersive days, we explore the path from cutting-edge bench research to clinical translation and therapeutic impact. Join us in Barcelona to collaborate, catalyze innovation, and shape the future of gene editing.

Conference Introduction

Welcome to the In Vivo Gene Editing Conference 2025 — a premier global gathering of scientists, clinicians, and innovators advancing the real-world application of gene editing. Over two immersive days, we explore the path from cutting-edge bench research to clinical translation and therapeutic impact. Join us in Barcelona to collaborate, catalyze innovation, and shape the future of gene editing.

6 Key Themes for the Gene Editing Conference 2025

  1. CRISPR and Beyond: Editing Technologies: Advances in CRISPR-Cas, base editing, prime editing, and novel platforms.
  2. Delivery Systems for In Vivo Editing: Viral and non-viral vectors, tissue targeting, and immunogenicity challenges. 
  3. Therapeutic Applications: Treating genetic, metabolic, and acquired diseases via in vivo editing. 
  4. Manufacturing & Scalability: GMP production of editors and vectors, scalability for clinical use. 
  5. Regulatory Pathways & Safety: Clinical trial design, long-term monitoring, and regulatory updates. 
  6. Ethics, Access & Global Equity: Ethical frameworks, equitable access, and implementation in LMICs.

Who Should Attend

Who Should Attend

  • Researchers & Scientists: Experts in genome engineering, delivery, and disease biology.
  • Biotech & Pharma Professionals: Involved in R&D, manufacturing, translational medicine, and regulatory strategy.
  • Investors & Venture Capitalists: Exploring the next wave of gene editing innovation.
  • Clinicians & Geneticists Focused on therapeutic adoption and patient outcomes.
  • Policy Makers & Bioethicists Guiding approval pathways and public trust in gene technologies.
  • Global Health Organizations & NGOs Advocating for equitable access and infrastructure

Industries Represented

  • Gene Therapy & Genomic Medicine 
  • Drug Delivery & Vector Design
  • Clinical Research & Translational Science
  • Biopharma & Manufacturing 
  • Investment & Venture Capital 
  • Health Policy & Global Health

Key Themes and Topics

  • Fundamentals of Flow Chemistry: The conference begins with an exploration of the fundamental principles and concepts underlying flow chemistry, including reactor configurations, reaction kinetics, and key advantages over traditional batch processes.
  • Applications Across Industries: Attendees will gain insights into the diverse applications of flow chemistry across various industries, including pharmaceuticals, fine chemicals, petrochemicals, materials science, and biotechnology. Case studies and success stories will highlight the practical implementation of flow chemistry in real-world manufacturing processes.
  • Advanced Techniques and Innovations: The conference will showcase cuttingedge developments and innovations in flow chemistry techniques, such as flow electrochemistry, flow photochemistry, and flow biocatalysis. Participants will learn about the latest methodologies and technologies pushing the boundaries of chemical synthesis and process optimization.
  • Practical Considerations and Challenges: Practical aspects of flow chemistry, including reactor design, instrumentation, automation, and scalability, will be discussed. Challenges such as regulatory compliance, safety considerations, and integration with existing processes will also be addressed.
  • Sustainability and Green Chemistry: Flow chemistry’s role in promoting sustainable manufacturing practices and reducing environmental impact will be a central theme. Attendees will explore how flow chemistry enables greener and more efficient chemical processes through reduced waste generation, energy consumption, and solvent usage.
  • Future Directions and Opportunities: The conference will conclude with a forward-looking perspective on the future of flow chemistry, highlighting emerging trends, opportunities for innovation, and potential applications in areas such as continuous manufacturing, personalized medicine, and advanced materials.

Day 1 – Technologies, Tools & Therapeutic Frontiers

Opening Keynote: The Gene Editing Era Begins
  • From proof-of-concept to patient trials
  • Pioneers in editing: reflections and vision for the future
Session 1: Emerging Editing Platforms
  • Base and prime editing advances
  • Engineered CRISPR systems and alternatives
  • Specificity, off-target minimization, and control
Coffee & Networking Break
Session 2: In Vivo Delivery Innovation
  • AAV, LNP, and new vector systems
  • Tissue specificity and targeting
  • Overcoming innate immunity and biological barriers
Networking Lunch
Session 3: Clinical Applications – Rare Diseases
  • Preclinical to clinical progress in monogenic disorders
  • Case studies: muscular dystrophy, retinal diseases, hemophilia
  • Patient selection, endpoints, and durability
Session 4: Manufacturing & CMC Strategy
  • Scalable production of gene editors
  • Purity, potency, and release criteria
  • Integrating QC and regulatory compliance
Panel Discussion: The Road to First Approvals
  • Timeline for the first in vivo gene editing drugs
  • Investor perspectives
  • Readiness of healthcare systems and providers

Day 2 – Translation, Regulation & Global Access

Session 5: Common Diseases & Regenerative Indications
  • Gene editing for cardiovascular, hepatic, and CNS disorders
  • Regenerative repair and cell in situ reprogramming
  • Early clinical data and pipeline highlights
Coffee & Networking Break
Session 6: Immunology, Oncology & Autoimmunity
  • In vivo editing for T cell modulation and cancer
  • Autoimmune disease targeting via epigenetic and genomic reprogramming
  • Combined modality approaches
Networking Lunch + Poster Session
Session 7: Ethics, Equity & Global Deployment
  • Ethical considerations in germline vs somatic editing
  • Strategies for affordable, scalable treatments
  • Partnerships for deployment in resource-limited settings
Session 8: Regulatory & Clinical Translation
  • EMA/FDA guidance on in vivo editing
  • Long-term follow-up frameworks
  • Real-world evidence and registries
Closing Panel: Editing the Future of Medicine
  • What’s next in platform convergence
  • Sustainable investment and infrastructure
  • Vision for 2030: Universal access to gene correction

Events

REGISTRATION FORM

DELEGATE PACKAGES:

For academics and nonprofit organization.
Includes the delegate package benefits

For small companies and startups.
Includes the delegate package benefits.

2 days of conference + discussion with industry experts.
Business lunches and cocktail reception

2 days of conference + discussion with industry experts.
2 nights luxury accommodation + transportation service from
airport to hotel. Businesslunches and cocktail reception

SPONSORSHIP PACKAGE

Our sponsorship packages are designed to offer optimum exposure for the budget that are available. For more information on the packages and to discuss your sponsorship requirements, please contact jakub.taborsky@twoknct.net

If you have any specific requirements that you feel are not covered by the packages available, then please do not hesitate to get in touch. We are always available to help you identify the options that suit your budget while maximizing your value and visibility at the conference.

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