Targeted Protein Degradation Barcelona Summit 2026

Join global leaders in TPD, degrader development, and E3 ligase biology for two days of insight, innovation, and partnering.

Targeted Protein Degradation Barcelona Summit 2026

Rewriting the Rules of Drug Discovery: From PROTACs to Molecular Glues

Welcome to the TPD Summit 2026

The Targeted Protein Degradation Summit 2026 is a premier global gathering of scientists, biotech leaders, and innovators transforming drug discovery through the degradation of disease-driving proteins.

Across two dynamic days in Barcelona, we’ll dive deep into the latest advances in PROTACs, molecular glues, novel ligase targeting, and emerging platforms like LYTACs and DUBTACs. From early discovery to the clinic, the field is evolving rapidly — and this event is your opportunity to stay ahead, form partnerships, and help shape the future of small-molecule precision medicine.

View The Full Programme

Who Should Attend

Medicinal Chemists & Structural Biologists: Driving rational degrader design and ligand discovery
Drug Discovery Scientists & Pharmacologists: Exploring new modalities for undruggable targets
Biotech & Pharma Executives: Leading R&D, BD, and clinical strategy in TPD programs
Clinical Development Leaders: Advancing degraders through preclinical and early-phase trials
Computational Biologists & Platform Engineers: Enabling in silico modeling, AI-driven design, and degrader screening
Investors & Venture Capitalists: Seeking the next wave of innovation in oncology, neuro, and inflammation
Regulatory & IP Professionals: Navigating new frameworks for novel mechanisms of action

Industries Represented

Small Molecule Drug Discovery
Biopharma & Degrader-Platform Biotech
Structural & Computational Biology
CROs & Preclinical Services
Medicinal & Synthetic Chemistry
Pharmaceutical IP & Legal
Venture Capital & Strategic Partnerships

Key Themes

Targeted Protein Degradation Comes of Age

Evolution of the field: From academic concept to clinical pipelines

Degrader Chemistry – PROTACs & Beyond

Rational design of heterobifunctional degraders

E3 Ligase Biology & Targeting

Expanding the E3 ligase toolbox

Structural Biology & Rational Design

Cryo-EM and crystallography in degrader discovery

Target Validation & Mechanistic Studies

Confirming degradation vs. inhibition

PK/PD, ADME & Bioavailability of Degraders

Pharmacokinetic challenges of bifunctional molecules

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Previous Events

Delegate satisfaction rate

Expert Speakers

Panel Discussions

Focused Driven Day

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6 Key Themes for the TPD Summit 2026

Innovations in Degrader Chemistry: Advancing bifunctional and monovalent degraders: PROTACs, glues, covalent binders
Expanding the E3 Ligase Toolbox: Novel ligases, tissue specificity, and targeted degradation strategies
Structural Biology & Rational Design: Ternary complex dynamics, modeling, and degrader-enabled selectivity
PK/PD, Bioavailability & Drug-Like Properties: Oral delivery, blood–brain barrier access, and degradation kinetics
Clinical Translation & Biomarker Strategies: First-in-human studies, pharmacodynamic endpoints, and trial design
Emerging Modalities in Protein Degradation: LYTACs, AUTACs, DUBTACs, and new frontiers in subcellular targeting

The TPD Summit 2026

The Targeted Protein Degradation (TPD) Barcelona Summit is Europe’s premier event dedicated to accelerating the development of next-generation degrader therapeutics. This two-day summit brings together scientific leaders, drug discovery innovators, and industry decision-makers to explore cutting-edge advancements in PROTACs, molecular glues, E3 ligase modulation, and ubiquitin-proteasome system targeting.

From early discovery to translational research and clinical pipelines, the summit offers a deep dive into the strategies that are redefining precision medicine.

The Targeted Protein Degradation (TPD) Barcelona Summit 2026

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